Takeda
PBPK Scientist
India · Work style not stated · Full time
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About the role
Description from the employer’s posting. Check the employer’s page for the current version.
- EmployerTakeda
- LocationIndia
- Work styleWork style not stated
- Employment typeFull time
- Employer posted
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.
Job Description
The Future Begins Here
At Takeda, we are leading digital evolution and global transformation. By building innovative solutions and future-ready capabilities, we are meeting the need of patients, our people, and the planet.
Bengaluru, the city, which is India’s epicenter of Innovation, has been selected to be home to Takeda’s recently launched Innovation Capability Center. We invite you to join our digital transformation journey. In this role, you will have the opportunity to boost your skills and become the heart of an innovative engine that is contributing to global impact and improvement.
Show full description
At Takeda’s ICC we Unite in Diversity
Takeda is committed to creating an inclusive and collaborative workplace, where individuals are recognized for their backgrounds and abilities they bring to our company. We are continuously improving our collaborators journey in Takeda, and we welcome applications from all qualified candidates. Here, you will feel welcomed, respected, and valued as an important contributor to our diverse team
Role Objectives:
A successful candidate will be responsible for design and implementation of PBPK models for small molecules and biotherapeutics supporting discovery and development programs. The accountabilities of this role include but are not limited to –
- Develop the PBPK framework for preclinical species and humans in Simcyp, Gastroplus, Matlab or other relevant software.
- Apply the models to new chemical entities for understanding tissue distribution to inform drug-target coverage and safety margins, predicting absorption and PK, and evaluating the impact of drug-drug interactions.
- Predict PK in special populations (e.g. hepatic or renal impairment patients, pediatrics, pregnant population, diseased population, etc.)
- Develop novel PBPK models to answer mechanistic questions (e.g., understanding complex clearance mechanisms, impact of biopharmaceutical properties on oral absorption characteristics, translation across species).
- Perform in silico ADME support as an enabler for PBPK model parameterization.
- Maintain input and output records and record workflow documentation.
- Collaborate with multi-functional project teams and functional group colleagues to identify data requirements for model development, and strategies for model application and use.
- Communicate recommendations from their modeling analyses to influence decisions in drug discovery and development.
- PhD degree with 5+ years relevant experience, or MS with 6+ years relevant experience, or BS with 8+ years relevant experience in Pharmaceutical Sciences, Drug Metabolism and Pharmacokinetics, Pharmacology or another relevant field.
- Strong understanding of the concepts of, and prior experience in PBPK modeling.
- Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of diverse modalities (e.g., small molecules, biotherapeutics), biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential.
- Knowledge and understanding of biopharmaceutics (e.g., solubility, dissolution, permeability, formulation and absorption mechanisms) with application to prediction of drug absorption.
- Proficient in one or more of the following modeling and simulation software – Simcyp, Gastroplus, PK-Sim, Matlab or another relevant software.
- Preferably experience in AI/ML, data science and programming (Python or R).
- Exceptional interpersonal, verbal communication and writing skills.
- Good organizational and planning skills.
- Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity.
- Strong quantitative, analytical and problem solving skills.
BENEFITS:
It is our priority to provide competitive compensation and a benefit package that bridges your personal life with your professional career. Amongst our benefits are:
Competitive Salary + Performance Annual Bonus
Flexible work environment, including hybrid working
Comprehensive Healthcare Insurance Plans for self, spouse, and children
Group Term Life Insurance and Group Accident Insurance programs
Employee Assistance Program
Broad Variety of learning platforms
Diversity, Equity, and Inclusion Programs
Reimbursements – Home Internet & Mobile Phone
Employee Referral Program
Leaves – Paternity Leave (4 Weeks) , Maternity Leave (up to 26 weeks), Bereavement Leave (5 calendar days)
ABOUT ICC IN TAKEDA:
Takeda is leading a digital revolution. We’re not just transforming our company; we’re improving the lives of millions of patients who rely on our medicines every day.
As an organization, we are committed to our cloud-driven business transformation and believe the ICCs are the catalysts of change for our global organization.
#Li-Hybrid
Locations
IND - Bengaluru - Research and Development
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
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At a glance
- Employment typeFull time
- Employer posted
- Added to ROLIVA
- Last checked
Skills in this posting
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