Research Scientist - Antibody Discovery

Key Responsibilities

Single B-cell Discovery Campaigns: Lead and execute end-to-end single-B-cell antibody discovery workflows, including immune-cell processing, FACS-based isolation of antigen-specific B cells, single-cell sequencing, and high-throughput molecular rescue of paired V-region sequences.

Immune Library Strategy: Design and construct high-diversity immune libraries from immunized animals. Implement robust NGS workflows for library characterization, monitoring diversity, and tracking selection dynamics across display platforms.

Panning & Selection: Manage complex panning and selection strategies using phage or yeast display to isolate rare, high-affinity binders from diverse immune repertoires.

Molecular Rescue & Cloning: Utilize high-throughput RT-PCR, nested PCR, and specialized cloning techniques to rescue heavy and light chain variable regions from single cells.

NGS Data Integration: Work closely with bioinformatics pipelines to integrate large-scale NGS datasets, enabling the rapid identification of novel antibody lineages and analyzing repertoire convergence.

Cross-Functional Collaboration: Represent the antibody discovery group in cross-functional project teams communicating discovery screening strategy

Discovery Documentation: Maintain precise electronic laboratory notebooks (ELN) and present technical discovery data at internal research forums and stakeholder meetings.

Evaluate and implement emerging antibody discovery technologies and workflows to improve throughput, repertoire diversity, functional screening, and discovery timelines.

Minimum Qualifications

Education:

PhD in Immunology, Molecular Biology, or Biotechnology with 0-3 years of relevant industrial experience in biologics discovery.

Technical Expertise:

Direct, hands-on experience with Single B-cell sequencing workflows and high-speed flow cytometry (FACS).

Expertise in NGS library preparation and associated molecular biology techniques.

Experience in Immune Library construction and display technologies

Advanced proficiency in high-throughput PCR and molecular cloning

Don’t meet every single requirement? Studies have shown underrepresented groups are less likely to apply to jobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role but don't necessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!

Elanco Benefits and Perks:

We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:

Multiple relocation packages

Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)

8-week parental leave

9 Employee Resource Groups

Annual bonus offering

Flexible work arrangements

Up to 6% 401K matching

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status

Elanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job‑related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.

#LI-MW1

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status

Elanco may use automated tools, including AI, to support parts of our recruitment process, such as reviewing applications against job‑related criteria and/or transferrable skills. These tools help ensure a consistent, structured evaluation, but they do not make hiring decisions. All decisions involve a human reviewer. For more information on how we handle personal data, please see our Elanco Workforce Privacy Notice.