Guidehouse

Scientist

United States · Work style not stated · Full time

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About the role

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EmployerGuidehouse
LocationUnited States
Work styleWork style not stated
Employment typeFull time
Employer posted24 Sep 2026

Job Family:

Scientist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are currently searching for Scientist to independently provide support services to satisfy the overall operational objectives of the NHLBI. This is a full-time, on-site opportunity in Gaithersburg, MD.

Advance the science in the laboratory through new procedures and discoveries.
Develop product-specific clinical formulations for vaccines and biotherapeutics for Phase I/II manufacturing under guidance of Federal Task Leaders including: project design, experimental design, study coordination within the Formulation Development group, timeline planning, and evaluation and protection of data integrity.
Serve as Formulation Development Subject Matter Expert for one formulation development team in the areas of: Formulation theory and experiment design, experiment execution and instrument operation, and data analysis and interpretation.
Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis on the development of novel research treatments.
Operate, troubleshoot and train others to use laboratory equipment and software.
Manage scientific equipment and resources (e.g. reagents, stocks of frozen sells, animal samples) including acquisition, documentation and storage.
Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.
Analyze, collate, and interpret data, utilizing in-depth knowledge of protein chemistry, protein formulation, and method theory, independently and in collaboration with team members.
Suggest alternative or complementary approaches to experiments.
Review, edit, and, as needed, write first drafts of papers detailing research efforts and results for publication in peer-reviewed journals,
Give posters and presentations detailing work at regional and national scientific meetings.
Lead communications within the VRC/VPP which includes participating in cross-functional teams, coordinating internal and interdepartmental activities, communicating with VRC Project Management regarding timelines and collaborating with other VRC and NIAID groups, and presenting data as needed to support other tasks.
Search existing literature for new and/or relevant techniques.
Develop assays for vaccine and biotherapeutic characterization under guidance of Federal Task Leaders which includes designing experiments, incorporating knowledge of Phase 1 assay development principles as outlined in ICH guidelines, and coordinating study activities with the Formulation Development group.
Evaluate and identify the instrumentation and related technologies for successful assay completion to advise Federal Task Leader, based on subject matter expertise.
Perform bench side sample analyses using both standard and advanced study specific analytical methods, as needed to further VRC Formulation Development projects and/or support other project teams.
Prepare technical reports and protocols documenting formulation, stability, and method development studies, including drafting, reviewing, editing, and verification of data.
Contribute to the drafting, reviewing and editing professional manuscripts for peer-reviewed journals based on results of formulation, stability, and method development studies and other similar details of research including drafting, reviewing, editing, and verification of data.
Provide general technical guidance and training to Formulation team members.
Oversee external service and execute routine maintenance and troubleshooting for one or more pieces of laboratory instrumentation.

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What You Will Need:

PhD. in Pharmaceutics, Chemical Engineering, Chemistry, or a related discipline is required
Minimum eight (8) of vaccine-related research, at least two years of experience of academic, industry, or government experience in protein vaccine or biotherapeutic formulation.
Strong experience with study design, execution, and interpretation in the areas of protein and/or vaccine formulation and stability.
Extensive hands-on expertise, including data analysis and underlying theory, with three or more of the following techniques: UV-visible, fluorescence, circular dichroism and/or IR spectroscopy, differential scanning calorimetry; isothermal chemical denaturation, rheology/ viscosity, particle characterization (dynamic/static light scattering, static light scattering, HIAC and/or MFI/ FlowCam).
Experience with software such as Origin, GRAMS, Prism, SigmaPlot, etc.
Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

Practical knowledge of current practices in protein therapeutic and/or vaccine development for clinical trials.
Extensive knowledge of protein chemistry, bioanalytical and biophysical properties of proteins and vaccines. Knowledge of protein formulation theory.
Strong oral and verbal communication skills.
Proficient with MS Office suite.

The annual salary range for this position is $130,000.00-$216,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

Medical, Rx, Dental & Vision Insurance

Personal and Family Sick Time & Company Paid Holidays

Parental Leave

401(k) Retirement Plan

Group Term Life and Travel Assistance

Voluntary Life and AD&D Insurance

Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

Transit and Parking Commuter Benefits

Short-Term & Long-Term Disability

Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

Employee Referral Program

Corporate Sponsored Events & Community Outreach

Care.com annual membership

Employee Assistance Program

Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

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