Principal Research Scientist - Medicinal Chemist

As a Principal Research Scientist in Medicinal Chemistry, you will be a key figure in our small molecule drug discovery engine, guiding the design and synthesis of innovative medicines that improve the health and well-being of animals. You will apply your scientificexpertiseto advance multiple therapeutic programs, from lead generation to development candidateselection. Partnering with a global, cross-functional team of scientists, you willleveragecutting-edgetechnologies like AI/ML and DNA-Encoded Libraries to solve complex chemical challenges. This is an exciting opportunity to make a significant impact on our discovery portfolio and help shape the future of our growing research team in Indianapolis.

Your Responsibilities:

Guidethe design and optimization of novel small molecules by applying advanced synthetic strategies and integrating biological, pharmacological, and ADME/PK data to manage Structure-Activity Relationship (SAR) campaigns.

Serve as a key medicinal chemistry figure on multidisciplinary project teams, collaborating with partners in Biology, Pharmacology, DMPK, Toxicology, and Computational Sciences to strategically advance discovery programs.

Manage and coordinate synthetic chemistry efforts with external Contract Research Organizations (CROs) and internal partners, ensuring the efficient execution of project goals and timelines.

Leveragecutting-edgedrug discovery technologies, including DNA-Encoded Libraries (DEL), computational chemistry, and AI/ML-enabled tools, to accelerate hit identification and lead optimization.

Promote scientific excellence and data integrity while providing mentorship and technical guidance to junior scientists, fostering a culture of innovation and collaboration.

What You Need to Succeed (minimum qualifications):

Education:PhD in Medicinal Chemistry, Organic Chemistry, ora relatedscientific discipline.

Experience:A minimum of 6 years of relevant industry experience in medicinal chemistry within a pharmaceutical, biotechnology, or animal health research environment.

Top Skills:Demonstratedexpertisein modern medicinal chemistry, including the design and multi-step synthesis of complex small molecules, and a strong understanding of Structure-Activity Relationships (SAR), pharmacology, and ADME/PK principles. Proven ability to autonomously manage scientific initiatives within a cross-functional team and manage external collaborations with CROs.

What will give you a strong candidate profile (preferred qualifications):

Postdoctoral experience.

Experience applying modern drug discovery technologies such as DNA-Encoded Libraries (DEL), computational chemistry, or AI/ML-enabled molecular design.

A strongtrack recordof advancing small-molecule discovery programs toward preclinical development,evidencedby significant patent and/or publication contributions.

Prior research experience in the animal health industry.

Expertise inpeptide chemistry, macrocycles, or related drug modalities.

Additional Information:

Travel:Less than 10%

Location:Global Elanco Headquarters - Indianapolis, IN - Hybrid Work Environment

Don'tmeet every single requirement? Studies have shown underrecognized groups are less likely to applytojobs unless they meet every single qualification. At Elanco we are dedicated to building a diverse and inclusive work environment. If you think you might be a good fit for a role butdon'tnecessarily meet every requirement, we encourage you to apply. You may be the right candidate for this role or other roles!

Elanco Benefits and Perks:

We offer a comprehensive benefits package focusing on financial, physical, and mental well-being while encouraging our employees to pursue our purpose! Some highlights include:

Multiple relocation packages

Two weeklong shutdowns (mid-summer and year-end) in the US (in addition to PTO)

8-week parental leave

9 Employee Resource Groups

Annual bonus offering

Flexible work arrangements

Up to 6% 401K matching

Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status

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